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For much of history, medicine had a basic problem: doctors could see symptoms long before they understood what caused them. That gap produced treatments based on humors, purging00 , counter-irritation, sedation, and the belief that a dramatic physical reaction meant something useful was happening. Some remedies occasionally relieved symptoms, but others added dehydration, infection, dependency, or physical injury to illnesses patients already had. Here are some of history’s clearest examples of medicine moving decisively in the wrong direction.

PEOPLE

Henry “Box” Brown found one of history's most unusual—and riskiest—paths to freedom from slavery.

PEOPLE

From NASA’s metric mix-up to forgotten ship doors and a 1.3-millimeter telescope error, discover the small mistakes that triggered enormous historical disasters.

PEOPLE

Heck Thomas built a legend as one of the most formidable lawmen of the American frontier—one bandit at a time.

PEOPLE

From murder inns and outlaw gangs to botched executions and frontier feuds, these bizarre Wild West crime stories reveal how strange, violent, and unpredictable life could become.

THINGS

Military blunders have toppled some of history’s greatest powers. From Persia and Carthage to the Inca and Songhai empires, these disastrous decisions helped entire states collapse.


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