Queen Anne ruled over one of the most prosperous era in Britain's history—but behind closed doors, her life was a waking nightmare. Anne had an absolutely horrific time when it came to motherhood. She was pregnant 17 times in 17 years, but only one of her children survived past two.
Now, centuries later, researchers believe they know why. Evidence suggests that she suffered from an autoimmune disease called Hughes syndrome, accounting for her 12 tragic miscarriages.